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Cancer risk from imaging-generated radiation exposure dependent on age, sex

Imaging modalities like dual-isotope nuclear scans yielded the highest doses of radiation.

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TCT 2009

The risk of developing cancer due to radiation exposure from computed tomography and nuclear scans is dependent to a large extent on the age and sex of the recipient.

According to a presentation by Stephen Balter, PhD, of the Columbia University Medical Center in New York, the doses of ionized radiation emitted by different imaging modalities are important for the acquisition of higher-quality images. Although higher doses of radiation result in higher-quality images, the risk for developing cancer in certain populations also increases with the amount of radiation received.

Relationship between age, sex, risk

Balter examined data from the National Cancer Institute to illustrate the relationship between age and the risk for developing future cancer. Using a 20-year-old female receiving an effective dose of 100 mSv as an example, Balter explained that the risk for developing radiation-induced cancer was 1.65%. The risk for the 20-year-old female patient developing cancer within the next 20 years without the radiation exposure was similar at 1.42%, making the risk for radiation-induced cancer more substantial for that patient. In a more typical, 60-year-old male patient, the same amount of radiation yielded a risk closer to that of the 20-year-old female patient (0.49%). The long-term risk for developing cancer absent the radiation exposure, however, was 27.71%.

“As the population gets older, the natural incidence of radiation goes up and the radiation risks go down, and so the relative importance of radiation goes down,” Balter said in his presentation.

Citing 2006 data from the National Council on Radiation Protection and Measurements, Balter showed that nearly half of the collective radiation dose in the United States dose results from medical radiation generated during CT scans (24%), nuclear medical scans (12%), interventional fluoroscopy (7%) and conventional radiography/fluoroscopy (5%). Dual-isotope nuclear scans delivered higher effective radiation doses than CT angiography, CT imaging for calcium scoring and CT angiography scans.

The radiation reduction techniques Balter highlighted varied according to modality. For fluoroscopy, radiation reduction could be accomplished with modification of the X-ray beam, lower frame rates and collimation. For CT, global reductions in beam intensity, beam path modulation and the avoidance of primary breast irradiation were cited as effective in lowering radiation exposure. Techniques for lowering exposure in nuclear scans included clinically tailored protocols and patient-specific radionuclide administration.

Balter S. Session 1. Presented at: Transcatheter Cardiovascular Therapeutics 2009; Sept. 21-25, 2009; San Francisco.

More About    Imaging  ·  CT  ·  Practice Management and Quality Care  ·  Patient care issues
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